Scientist
Company: Antharis Therapeutics, Inc.
Location: San Diego
Posted on: October 20, 2024
Job Description:
We are currently offering a fantastic career opportunity for a
highly motivated and experienced antibody discovery/development
scientist to join Antharis Therapeutics, a pre-clinical company
based in San Diego. The company is committed to discovering and
developing novel immunotherapeutics (monoclonal antibodies and
antibody-drug conjugates) for an array of disease states. The
approaches for antibody discovery, including hybridoma technology,
aim to streamline the development of lead candidates for entering
the clinic in an expedited fashion.We are seeking a Scientist I
with hands-on experience in antibody discovery using hybridoma
technology. Responsibilities will include designing and executing
immunization and screening strategies to generate panels of
antibodies that target various proteins in the oncology and
immune-oncology fields. The candidate must have in-depth knowledge
of current state-of-the-art antibody generation technologies and be
able to apply this to practice at the bench.Essential Job
Functions
- Design and execute on approaches to immunize mice and perform
electrofusions.
- Design and execute hybridoma cell culture using both liquid and
semi-solid media.
- Design and execute screening protocols using both ELISA and
flow cytometry methods.
- Proactively propose strategies to project teams to generate the
target antibodies.
- Execute on all stages of antibody generation to deliver diverse
panels of antibodies meeting the required criteria.
- Integrate data from multiple sources (binding, epitope,
sequences, and protein characterization) to generate a complete
data package for antibody characterization.
- Maintain detailed records of all experiments in ELN and using
in-house databases and tracking systems.
- Direct a group of scientists abroad to facilitate the hybridoma
generation workflow.
- Responsible for delivering both data analysis packages as well
as purified antibodies to project teams.
- Trouble-shoot and optimize protocols and propose creative
solutions to improve efficiency to existing processes.
- Proactively evaluate new technologies, instrumentation, and
assays available from the literature or scientific meetings to
improve in-house platforms.
- Implement and routinely run disease-relevant in-vitro and
in-vivo tests to probe for antibody therapeutic efficacy.
- Coordinate and carry-out in-vitro and in-vivo tests to probe
asset efficacy in relevant in-vitro and in-vivo disease
models.
- Plan and execute mechanism of action studies on the Company's
asset pipeline.
- Ensure rapid and high-quality project advancement.
- Responsible for day-to-day bench operations and leadership over
each project inflection point, including: target identification and
discussions, developing project plans, carrying out experiments
from conception to asset development and testing, and controlling
project execution to ensure completion of projects to scope,
schedule and budget.
- Responsible for ensuring that project risks, both technical and
managerial, are identified and appropriately addressed, as well as
develop risk mitigation plans.
- Regularly assess and report the status of the projects directly
to the CSO and the VP of Research & Development.
- Drive day-to-day project activities to achieve results
including solving technical and other project challenges, managing
resource conflicts, breaking down barriers to meet product
development deadlines, and company goals and objectives.Position
Requirements
- Ph.D. and postdoctoral in Molecular and Cell Biology,
Biochemistry, or advanced degree with 5+ years of relevant
experience.
- Demonstrated experience successfully executing antibody
generation using hybridoma approaches to identify antibody panels
is required.
- Extensive experience with antibody binding assays and analysis,
especially ELISA, biosensor, and multi-color flow cytometry is
required.
- Experience with PCR, molecular cloning, and transfection of
mammalian cells.
- Strong experience in Excel, Graphpad Prism, flow cytometry
analysis software is required.
- Strong focus, motivation, and commitment to hands-on lab work
is required.
- Excellent organization and communication skills.
- Ability to multi-task in a fast-paced environment.
- Ability to work and thrive in a collaborative, cross-functional
team-oriented environment.
- Legally authorized to work in the US.
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Keywords: Antharis Therapeutics, Inc., Temecula , Scientist, Other , San Diego, California
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